AnestAssist PK/PD is an educational tool used for understanding and visualizing the pharmacokinetics, pharmacodynamics, and interactions of commonly used anesthetic drugs.

Anesthesiologists, CRNA’s, veterinarians, and other clinicians involved with anesthesiology, from residents to the very experienced, will find AnestAssist a valuable tool for understanding rational dosing strategies tailored to individual patients.

Mathematical models, published in peer reviewed anesthesia journals (see, which take into account patient weight, age, and gender, are used to estimate and chart:
Plasma Concentration (IV drugs)
Alveolar Concentration (Inhaled agents)
Effect Site Concentration
Probability of Effect (individual and combined drug interactions)
Analgesia: No response to laryngoscopy
Sedation: OAA/S < 2
NMB: T1/T0=50%

IV drugs included: Propofol, Remifentanil, Fentanyl, Alfentanil, Sufentanil, Dexmedetomidine, Ketamine, Lidocaine, Morphine, Midazolam, Atracurium, Cisatracurium, Rocuronium, and Vecuronium.

Inhaled agents included: Sevoflurane, Isoflurane, Desflurane, Enflurane, Halothane, and Nitrous Oxide.

Interactions modeled: Propofol, Sevoflurane, or Isoflurane with any combination of Remifentanil, Fentanyl, Alfentanil, or Sufentanil.

Users can add drugs and PK/PD model parameters to the system in addition to those included above.

Real-Time Case Capture: Drug entry system facilitates recording drugs administered real-time or retrospectively from intra-operative record. Save to Case Library for later review.

Case Library: Save actual cases or design and add your own cases to the library to record and demonstrate dosing strategies for a variety of patient types and drugs.

AnestAssist runs an enhanced user interface full screen natively on the iPad and in standard mode on the iPhone/iPod. The core functionality is the same on both.

Please see for detailed information.

For Educational Use Only

What’s New

Version 1.9

This app has been updated by Apple to use the latest Apple signing certificate.

Fixed incompatibilities with iOS 8 which caused the app to freeze. Updated the user interface to iOS 7/8 look and feel.

Ratings and Reviews

5.0 out of 5
1 Rating

1 Rating

etherDad ,

Great app - I use it in the OR regularly

I've been using this for almost a year, and it is fantastic. I teach residents and I use this to show the difference that solubility coefficients make in short vs long cases, how WHEN you give fentanyl has a profound effect on plasma level and Ce, how to plan sufentanil infusions, TIVA, neuromuscular blockade. Very easy to use, and now I have a library of real cases and simulated cases to review with my residents.

Ozcan ,

I just used it-again!

I had this app since it was newly released, and have used it almost daily since then. I just modeled cisatracurium infusion and glanced at the PK/PD (T1 50%) to help with our understanding of the dosing. Then, with my resident, we plotted the sevoflurane/fentanyl and looked at the interaction model by Manyam. If you are administering anesthesia, buy it! If you are using TIVA as your technique, you should have bought it when it came out!

Mfiedler ,

Not worth the price. Think twice.

Idea is great. Data entry is cumbersome. Time hard to track; you must enter in clock hours but is displayed from time 0. Graphs truncate at seemingly random times from time zero, even if curve has not decayed to baseline. Graph scale doesn't change if you use larger doses than the software designer anticipated (as many may do with fentanyl, for example.) It doesn't take long to regret making the purchase price.


Palma Healthcare Systems, LLC
3.8 MB

Requires iOS 7.0 or later. Compatible with iPhone, iPad, and iPod touch.



Age Rating
Infrequent/Mild Medical/Treatment Information


  • Family Sharing

    With Family Sharing set up, up to six family members can use this app.

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