PathoPlay: Pathophysiology
Ace disease & drug mechanisms
Free · In‑App Purchases · Designed for iPad. Not verified for macOS.
Sabotage Mode is here. Disrupt 100 healthy pathways using pathogens, drugs, or autoimmune triggers. Plus, the new Mechanisms tab lets you study by cascade or system.
PathoPlay teaches pathophysiology and pharmacology by mechanism, not memorization. Trace how diseases start, how drugs treat them, and how the same molecular cascades recur across organ systems.
Can you connect the chain?
Portal hypertension → splanchnic capillary pressure → fluid transudation → ascites. Every link matters. Miss one, and the pathway breaks.
Now treat it.
Five drugs in your cart. Only one hits the right molecular target. Choose wrong, the cascade continues.
Now sabotage it.
A healthy cascade. Five insults: pathogens, toxins, autoantibodies, stressors. Only one disrupts the pathway at the right node. Drop it correctly, and watch the disease unfold step by step.
FIVE MODES
Chain — Drag and connect steps from trigger to clinical outcome.
Reverse — Start with a clinical finding and trace backward to the root cause. How attendings think.
Versus — Two similar diseases side by side. Fill in the gaps that distinguish them.
Treat — Drag the correct drug onto the right molecular target to block the cascade. Pharmacology by mechanism.
Sabotage — Drop the right pathogen, toxin, or autoantibody onto the node it disrupts. Watch the cascade fail in real time.
PLUS
Mechanisms — Study horizontally instead of by body system. 28 immunopathology, toxin, and hemodynamic clusters span every mode.
Daily Challenge — One new chain every day. Build your streak in under 3 minutes.
650 PUZZLES ACROSS 10 BODY SYSTEMS
Cardiovascular, Respiratory, Renal, GI & Hepatology, Neurology, Endocrine, Infectious Disease, Hematology, Reproductive, Rheumatology — pathophysiology, pharmacology, and mechanism-disruption in every system.
Sabotage highlights: H. pylori, HBV cccDNA, C. difficile, doxorubicin cardiotoxicity, anti-PLA2R membranous, falciparum malaria, prion disease, MS, Hashimoto, Graves, TTP, HIT, APS, HPV cervical cancer, drug-induced lupus, statin myopathy.
WHO IT'S FOR
Medical students preparing for USMLE Step 1 and Step 2 CK. Nursing students mastering mechanisms for NCLEX. PA, NP, and pharmacy students building clinical reasoning foundations. Anyone who wants to understand why diseases happen and how drugs work.
WHY IT WORKS
Most study tools ask you to recall facts. PathoPlay asks you to think with mechanism as the unit of reasoning. Five different ways to engage the same molecular reality builds understanding that survives exam pressure and translates to clinical practice.
Every puzzle ends with a clinical pearl referenced to standard medical textbooks.
From the makers of MedDiagnosis (clinical case simulator) and Kinetics (USMLE biochemistry).
ACCESS
200 chains free across all 10 body systems
One-time purchase unlocks all four premium modes, the Mechanisms browse, and all future content, yours forever
No subscriptions, no ads, fully offline
Evidence-based content referenced to Robbins & Cotran, Harrison's, Guyton & Hall, Goodman & Gilman's, Pathoma, Nat Rev Dis Primers, NEJM, and Lancet.
Support: contact@diagnosticstudios.com
Educational use only. Not for clinical decision-making.
USMLE® is a trademark of NBME/FSMB. No affiliation or endorsement.
Ratings & Reviews
Introducing Sabotage Mode: disrupt 100 healthy pathways with the right pathogen, toxin, or autoimmune trigger.
Plus: cross-mode Mechanisms browse, related-puzzle links, and a faster results screen.
The developer, Helena Kaso, indicated that the app’s privacy practices may include handling of data as described below. For more information, see the developer’s privacy policy .
Data Not Linked to You
The following data may be collected but it is not linked to your identity:
- Identifiers
- Usage Data
- Diagnostics
Accessibility
The developer has not yet indicated which accessibility features this app supports. Learn More
Information
- Seller
- Helena Kaso
- Size
- 60.8 MB
- Category
- Medical
- Compatibility
Requires iOS 15.1 or later.
- iPhone
Requires iOS 15.1 or later. - iPad
Requires iPadOS 15.1 or later. - iPod touch
Requires iOS 15.1 or later. - Mac
Requires macOS 12.0 or later and a Mac with Apple M1 chip or later. - Apple Vision
Requires visionOS 1.0 or later.
- iPhone
- Languages
- English
- Age Rating
16+
- 16+
- Frequent
Medical Treatment information
- In-App Purchases
Yes
- PathoPlay Premium $12.99
- Copyright
- © 2026 Diagnostic Studios