Version 1.8 expands the hemodynamic modeling and Echo Reference workspaces. HEMODYNAMIC MODELING • Expands Mechanics of Blood Circulation - Reader's Notes to Chapters 1–8 with equation-centered explanations, explicit model assumptions, independent diagrams, and chapter-specific simulations • Adds an integrated systemic-pulmonary circulation laboratory with interactive controls and pressure, flow, volume, energy, reserve, and conservation displays • Adds The Fluid Mechanics of Aortic Stenosis — Reader's Notes, integrating Colin Clark's paired 1976 studies with source links, uncertainty statements, and a reader-developed native simulation • Improves chapter navigation and return-to-section controls for long-form educational content ECHO REFERENCE • Reorganizes major pathways into clearer clinical and hemodynamic groups • Refines Diastolic Function into five focused categories covering orientation and physiology, acquisition and reference standards, diagnostic classification, filling-pressure assessment and grading, and integrated interpretation and reporting • Places rhythm, pacing, valve, heart-failure, pulmonary-hypertension, cardiomyopathy, and pericardial material in more specific pathways • Distributes supplemental pressure indices and maneuvers into the acquisition, LAP/LVEDP, disease-specific, and reporting contexts where they are most relevant • Improves related-route navigation, source organization, and content consistency GENERAL • Includes interface, navigation, and reliability refinements

Version 1.7 adds two separate major educational systems: • Hemodynamic Simulations: reader-developed one-circulation, two-circulation, and one-beat models with circuit visualizations, scenario controls, calculated pressure and flow results, and explicit model limitations. • Echo Reference: searchable adult echocardiography equations, thresholds, clinical pathways, compact tables, interpretive cautions, source anchors, citations, and available paper links. The hemodynamic laboratory is kept separate from the book-based reader’s notes, and Echo Reference is presented as an independent quick-reference and source-navigation tool. Neither feature provides diagnosis, treatment recommendations, or patient-specific clinical decisions.

Version 1.6 expands the Medical Equations workspace. New and refined items: • eGFR is now a separate top-level calculator • CKD-EPI 2021, CKD-EPI 2009, and MDRD eGFR are shown together • CKD/ESRD GFR staging table highlights the current result • Korean HIRA reference reminders were added for CKD anemia and erythropoietin-related review criteria • Quick Ventilator Settings and RSBI are now organized as ventilation-specific equation tools • Compliance and Ti/T-pause are now separated inside Miscellaneous Equations • Medical Equation Library now includes an auto-scroll option after calculator selection This version also refines concise disclaimer text for equation tools. The calculations are provided for education, model inspection, and quick reference reminders only. They do not direct diagnosis, treatment, ventilator management, prescription, reimbursement, claim submission, or patient-care decisions.

Version 1.5 updates Project nGene.org® with ICA source-library expansion and add-on workflow refinements. New and improved: • Expanded ICA source library with UMich heart sound examples • Added HLS-CMDS lung sound examples • Added visible source attribution and license information inside ICA • Updated ICA source selection to use one heart source and one lung source • Improved optional source-pool loading behavior • Improved Test-Lung and EKG unsupported-device guidance • Improved Settings navigation behavior from iPad-focused add-ons • Refined Add-Ons Settings layout The added heart sound pool is attributed to the UMich Heart Sound & Murmur Library under Creative Commons Attribution 4.0 terms, except where otherwise noted. The added HLS-CMDS lung sound dataset is licensed under CC BY 4.0.

Version 1.4 adds the Virtual EKG Simulator educational add-on. New features: • Added optional Virtual EKG Simulator • Added rhythm selection for simplified ECG waveform exploration • Added heart-rate and signal-quality controls • Added 3-lead, limb-lead, precordial-lead, and 12-lead display modes • Added 3D Electrical Vector View • Added Heart and Electrode Map • Added live EKG waveform sweep visualization • Added iPad landscape-optimized EKG workspace • Added floating Settings exit behavior for the EKG add-on • Updated Add-Ons ordering in Settings • Updated enabled add-on tab ordering after the MDRO tab This update expands Project nGene.org® with an educational EKG waveform simulator while preserving the existing Virtual Ventilator Test-Lung, Echocardiography Recognition, IVNT, Equations, and core modeling modules.

Version 1.3 expands the Virtual Ventilator Test-Lung educational add-on. New features: • Added PS, SIMV, PRVC, PC, and VC mode selection • Added mode-specific clinician controls • Added mode-specific monitored values • Added Quick Ventilator Setting Calculator • Added PBW, VT, BSA, MV, RR, and PC driving-pressure calculations • Added RSBI Calculator • Added Static and Dynamic Compliance Calculator • Added Ti and T-pause Calculator • Improved iPad landscape workflow • Improved Test-Lung exit behavior for non-ideal device or window states • Moved detailed mode explanations into the Information screen to preserve workspace space • Refactored calculator views for cleaner internal structure This update improves educational comparison of ventilator modes, waveform behavior, and simplified respiratory mechanics.

Version 1.2 adds the Virtual Ventilator Test-Lung educational add-on. New features include: • Interactive pressure, flow, and volume waveform visualization • Pressure Support and Pressure Control educational modes • Adjustable respiratory mechanics and patient-drive parameters • Single-compartment lung model simulation • iPad landscape optimized waveform workspace • Improved Add-On integration and interface organization Additional improvements: • General UI refinements • Stability improvements • Internal architectural cleanup for modular educational add-ons

Version 1.1 • Added an optional Echocardiography Recognition educational preview. • Provides camera-based learning support for echocardiography view orientation and anatomy scaffolding. • Includes PSAX/PLAX-style classification and AV/PV object scaffolding for educational exploration. • Added camera permission support for the new module. • Preserved existing hemodynamic modeling, medical equations, ICA, chest vascularity, MDRO, and IVNT workflows. This feature is intended for education and model exploration only. It is not a diagnostic tool and does not provide clinical recommendations.