Immunity: Pathogen Defense
Immune System Roguelite
Free · Designed for iPad. Not verified for macOS.
Fight through 10 organs as a macrophage.
Battle real pathogens. Face the final enemy,
Cancer. The body is counting on you.
YOU ARE THE LAST LINE OF DEFENSE.
Play as a macrophage — the immune system's most powerful cell — and fight through 10 zones of the human body in this biology-based action roguelite.
THE BODY IS UNDER ATTACK.
From the Lymph Node to the Heart, real pathogens have invaded every organ. Bacteria. Parasites. Viruses. Kidney stones. Blood clots. Each zone brings new enemies grounded in actual cell biology — every creature, ability, and mechanic is based on how the immune system really works.
BUILD YOUR IMMUNE RESPONSE.
Every run is different. Collect 27+ adaptations and abilities as you progress — Cytokine Burst, Fever Mode, Phagocytosis, Neutrophil Swarm, Complement Cascade, and more. Stack upgrades. Build synergies. Adapt to every threat.
10 ZONES. 10 BOSSES.
▸ Lymph Node — face the Dormant Sentinel
▸ Lungs — battle the Pneumonia Mass
▸ Bloodstream — confront the Sepsis Herald
▸ Stomach — destroy H. Pylori Overlord
▸ Brain — survive the Neuroinflammation Prime
▸ Liver — fight the Cirrhosis Node
▸ Small Intestine — stop the Tapeworm Queen
▸ Large Intestine — dismantle the Bacterial Megacolony
▸ Kidneys — shatter the Nephrolithic Golem
▸ Heart — expel the Myocardial Invader
THEN FACE THE FINAL BOSS.
Cancer. The body's own cells gone wrong. A corrupted mirror of yourself. Three phases. Endless copies. No easy victory.
ROGUELITE THAT RESPECTS YOUR TIME.
▸ Quick runs — each zone takes minutes
▸ Permanent upgrades carry between runs
▸ No energy systems. No paywalls. Play anytime.
▸ Every run feels different — 27+ items, abilities, and upgrades
▸ One more run feeling that turns five minutes into an hour
LEARN WHILE YOU PLAY.
Every enemy is a real pathogen. Every ability is a real immune response. Immunity is the only roguelite built on actual immunology — making it genuinely educational without ever feeling like homework.
▸ E. coli that groups and reforms
▸ Fibrin clots that regenerate HP
▸ Calcium oxalate crystals with mineral armor
▸ Platelet swarms that recruit more platelets
▸ A Cancer boss that proliferates when damaged
Can the immune system hold?
The developer, DALTON SANDOR DRISCOLL, indicated that the app’s privacy practices may include handling of data as described below. For more information, see the developer’s privacy policy .
Data Not Collected
The developer does not collect any data from this app.
Accessibility
The developer has not yet indicated which accessibility features this app supports. Learn More
Information
- Seller
- DALTON SANDOR DRISCOLL
- Size
- 359.9 MB
- Category
- Games
- Compatibility
Requires iOS 14.3 or later and a device with the A12 Bionic chip or later.
- iPhone
Requires iOS 14.3 or later and a device with the A12 Bionic chip or later.
• iPhone XS
• iPhone XS Max
• iPhone XR
• iPhone 11
• iPhone 11 Pro
• iPhone 11 Pro Max
• iPhone SE (2nd generation)
• iPhone 12 mini
• iPhone 12
• iPhone 12 Pro
• iPhone 12 Pro Max
• iPhone 13 Pro
• iPhone 13 Pro Max
• iPhone 13 mini
• iPhone 13
• iPhone SE (3rd generation)
• iPhone 14
• iPhone 14 Plus
• iPhone 14 Pro
• iPhone 14 Pro Max
• iPhone 15
• iPhone 15 Plus
• iPhone 15 Pro
• iPhone 15 Pro Max
• iPhone 16
• iPhone 16 Plus
• iPhone 16 Pro
• iPhone 16 Pro Max
• iPhone 16e
• iPhone 17 Pro
• iPhone 17 Pro Max
• iPhone 17
• iPhone Air
• iPhone 17e
• iPhone 18 Pro
• iPhone 18 Pro Max
• iPhone Duo - iPad
Requires iPadOS 14.3 or later and a device with the A12 Bionic chip or later.
• iPad Pro (11‑inch)
• iPad Pro (11‑inch) Wi‑Fi + Cellular
• iPad Pro (12.9‑inch) (3rd generation)
• iPad Pro (12.9‑inch) (3rd generation) Wi‑Fi + Cellular
• iPad mini (5th generation)
• iPad mini (5th generation) Wi‑Fi + Cellular
• iPad Air (3rd generation)
• iPad Air (3rd generation) Wi‑Fi + Cellular
• iPad Pro (11‑inch) (2nd generation)
• iPad Pro (11‑inch) (2nd generation) Wi‑Fi + Cellular
• iPad Pro (12.9‑inch) (4th generation)
• iPad Pro (12.9‑inch) (4th generation) Wi‑Fi + Cellular
• iPad Air (4th generation)
• iPad Air (4th generation) Wi‑Fi + Cellular
• iPad (8th generation)
• iPad (8th generation) Wi‑Fi + Cellular
• iPad Pro (11-inch) (3rd generation)
• iPad Pro (11-inch) (3rd generation) Wi‑Fi + Cellular
• iPad Pro (12.9-inch) (5th generation)
• iPad Pro (12.9-inch) (5th generation) Wi-Fi + Cellular
• iPad mini (6th generation)
• iPad mini (6th generation) Wi-Fi + Cellular
• iPad (9th generation)
• iPad (9th generation) Wi-Fi + Cellular
• iPad Air (5th generation)
• iPad Air (5th generation) Wi‑Fi + Cellular
• iPad (10th generation)
• iPad (10th generation) Wi‑Fi + Cellular
• iPad Pro (11‑inch) (4th generation)
• iPad Pro (11‑inch) (4th generation) Wi‑Fi + Cellular
• iPad Pro (12.9‑inch) (6th generation)
• iPad Pro (12.9‑inch) (6th generation) Wi‑Fi + Cellular
• iPad Air 11-inch (M2)
• iPad Air 11-inch (M2) Wi-Fi + Cellular
• iPad Air 13-inch (M2)
• iPad Air 13-inch (M2) Wi-Fi + Cellular
• iPad Pro 11-inch (M4)
• iPad Pro 11-inch (M4) Wi-Fi + Cellular
• iPad Pro 13-inch (M4)
• iPad Pro 13-inch (M4) Wi-Fi + Cellular
• iPad mini (A17 Pro)
• iPad mini (A17 Pro) Wi-Fi + Cellular
• iPad (A16)
• iPad (A16) Wi-Fi + Cellular
• iPad Air 11-inch (M3)
• iPad Air 11-inch (M3) Wi-Fi + Cellular
• iPad Air 13-inch (M3)
• iPad Air 13-inch (M3) Wi-Fi + Cellular
• iPad Pro 11-inch (M5)
• iPad Pro 11-inch (M5) Wi-Fi + Cellular
• iPad Pro 13-inch (M5)
• iPad Pro 13-inch (M5) Wi-Fi + Cellular
• iPad Air 11-inch (M4)
• iPad Air 11-inch (M4) Wi-Fi + Cellular
• iPad Air 13-inch (M4)
• iPad Air 13-inch (M4) Wi-Fi + Cellular - Mac
Requires macOS 11.0 or later and a Mac with Apple M1 chip or later. - Apple Vision
Requires visionOS 1.0 or later and a device with the A12 Bionic chip or later.
- iPhone
- Languages
- English
- Age Rating
4+
- 4+
- Contains
Advertising
- Copyright
- © 2026 RnDsRnD