Ask Your Slide has its own tab under AI, next to Analysis and Quantify, with its own data notice and response language, and the AI button opens it. After a Quantify run on an IHC slide, SlideScope offers to score it with Ask Your Slide (H-score and percent DAB-positive nuclei) and types the question in for you; after a few measurements or notes on your own file, it offers to share the view with your findings. These suggestions appear at most once a week and never while you work. The start screen no longer shows an "Open a file" label that looked like a button.

SlideScope no longer appears to freeze when a file fails to open quickly, such as a VSI slide without its folder or a file that was moved: the Loading window could cover the error message, and on a Mac the app had to be force-quit. Motic MDSX whole-slide images now open; support for them is new, so if an MDSX slide looks wrong, tell us through Help > Contact Support. Check your files now looks inside .zip files: it lists the slides inside, says they open after extraction, and flags a slide whose companion folder is missing from the zip. Viewer and helper files from patient CDs are labelled as not an image, and a DICOMDIR picked on its own stands for its whole disc. When an MRXS, VSI, VMS or VMU slide is missing its companion files, the check and the open error now name the exact folder or files to copy next to it, and a VSI whose image folder is empty or incomplete is no longer reported as damaged. A one-time tip shows that SlideScope comes in 10 languages, with a button that opens the language setting. A new app icon and logo.

v1.23.1 - Ask Your Slide, rolling out gradually to SlideScope plans over the coming days: ask a question about the open image and SlideScope counts nuclei, scores IHC (percent positive, H-score and Allred), measures and finds the most crowded areas on your computer, with every number from a local measurement linked to the exact view. Every answer keeps its evidence: re-run it without the AI, export it with a methods text and the Quantify results, or turn its views into a figure. With view images turned off, your image never leaves your computer. Check your files now also counts the file formats SlideScope does not recognize yet (only the extension, how many and the approximate size), to help choose the next formats to support.

Ask Your Slide, rolling out gradually to SlideScope plans over the coming days: ask a question about the open image and SlideScope counts nuclei, scores IHC (percent positive, H-score and Allred), measures and finds the most crowded areas on your computer, with every number from a local measurement linked to the exact view. Every answer keeps its evidence: re-run it without the AI, export it with a methods text and the Quantify results, or turn its views into a figure. With view images turned off, your image never leaves your computer. Check your files now also counts the file formats SlideScope does not recognize yet (only the extension, how many and the approximate size), to help choose the next formats to support.

Ask Your Slide, rolling out gradually to SlideScope plans over the coming days: ask a question about the open image and SlideScope counts nuclei, scores IHC (percent positive, H-score and Allred), measures and finds the most crowded areas on your computer. Every number comes from a local measurement and links back to the exact view. Every answer keeps its evidence: re-run it on your computer without the AI, export it with a methods text and the Quantify results, or turn the views it cites into a figure. With view images turned off, your image never leaves your computer. Ask Your Slide works with the keyboard and screen readers. Dataset thumbnails are always written whole. Includes everything in 1.22.0.

Playing through focal planes or time points while signed in no longer reloads your notes and regions for every frame; they load for the plane where playback stops. When our servers ask the app to slow down, SlideScope now waits the time they ask for before trying again, so the rest of your account keeps working. Includes everything in 1.21.0.

Five more file formats open in SlideScope: Philips iSyntax and KFBio KFB whole-slide scans, ICS images from Huygens, Gatan DM3/DM4 electron micrographs (spectrum images get an Energy slider, diffraction patterns a scale bar in nm-1) and Olympus SIS images, each with its scale and metadata. The annotations drawn in Hamamatsu NDP.view now appear over your NDPI slides, and you can copy them into your measurements. Got slides as a .zip? Open the archive: SlideScope shows what is inside, extracts it next to the archive and opens it.

• Check your files now leads with the answer: when your file opens, it is shown large with every tool you can use on it, followed by the few steps to open it in SlideScope. • Home now speaks to every kind of image SlideScope opens: microscopy, whole slides and medical scans. • Diagnostics now include, for every file you open, its format and whether it opened, as extensions and error codes only, never file names, paths or pictures, so we fix the formats that fail most first. You can turn this off with the other diagnostics in Settings > Privacy.

Check Your Files (File menu): choose files or whole folders and SlideScope reads each one on your Mac, then shows whether it opens, a small preview, its channels, focal planes, time points, scenes and pixel size, and the tools you can use on it. Nothing is uploaded. Files that do not open are explained in plain words, with a way to tell us about them. Also in this update: opening a SlideScope Cloud image larger than 2 GB, your own from another computer or one shared with you, no longer stops partway; play through focal planes and time points; and a refreshed look.

SlideScope 1.16.0 includes fixes and improvements. Full release notes: https://slidescope.science/en/release-notes/

Large compressed TIFF images open without needing gigabytes of free disk space for a temporary copy, and they open faster. If a file still needs more temporary space than your disk has, the message now says how much it needs and how much is free. In the app downloaded from slidescope.science, opening your own images for the first time now starts with a short welcome: what your files get in SlideScope, and a free 3-day trial you can start in one step; plans and prices come after that first step.

After an image opens, SlideScope tells you what it just did, such as the slide's size and how long it took to open. On the free sample images, a Try this tip suggests a feature that suits the image, with a Show me button that does it for you. Error messages are now in plain language and say what you can do next. Mac App Store: slides in folders you allow, including MIRAX (.mrxs) slides with their data folder, and Safe Copy to a folder you choose are handled more reliably. Diagnostic logs and support reports no longer include the names of your folders.

SlideScope 1.13.0 includes fixes and improvements. Full release notes: https://slidescope.science/en/release-notes/

Sharing is simpler: the Share dialog asks one question, whether to share a clean copy, and keeps the other settings under Options. While a share link is made you see its progress, in the dialog and on the toolbar's Cloud button, and you can stop it with Stop sharing. Opening Share again while a link is on its way now follows that share instead of reporting that the clean copy didn't upload. Without a subscription, paid tools stay visible with a lock and show how to get them. Text no longer gets cut off in dialogs and panels at larger text sizes and display scaling. Includes everything in 1.11.0.

3DHISTECH MIRAX (.mrxs) slides saved with JPEG XR, as newer Pannoramic scanners can do, now open: SlideScope reads them itself where the standard slide library refuses them. When a MIRAX, VMS or VMU slide will not open, the problem report now includes the size and file count of the slide's data folder, so we can tell a missing or incomplete copy apart faster. Includes everything in 1.10.0: 18 more file formats with their instrument details.

A redesigned Windows installer: it now has SlideScope's own dark look, opens with a clear welcome page, explains every step in plain words and shows a progress bar that matches the app. Installed copies update exactly as before, and nothing changes on a Mac.

An SVS slide with one damaged zoom level, usually an incomplete or damaged copy, now opens: SlideScope shows that zoom level from the healthy parts of the file and says that part of the file is damaged, instead of refusing the whole slide. An SVS slide whose image data is damaged throughout now asks you to copy it again from the original source instead of showing a technical error. In the version from slidescope.science, the free trial now counts each image once: reopening an image you have already opened no longer uses up another of your 10 images.

The buttons on the start screen now say exactly what they open (Open file, Open folder, Open link) and carry matching icons. A CZI file that has no image data yet (still being saved by ZEN, a copy that did not finish, or an online-only OneDrive or Dropbox file) now says so and asks you to copy it again, instead of reporting missing scenes. A MIRAX slide whose Slidedat.ini was damaged while copying is now reported as damaged, with a prompt to copy the slide folder again, instead of as a layout SlideScope cannot open.

Compare mode treats each side as its own viewer: zooming, panning and the right-click menu act on the image under the pointer, keyboard and menu commands go to the image you last worked in (it is outlined), the right image has its own zoom controls, scale bar and file menu, and the two views move together only when you turn on Link views. The free preview now includes 10 images (up from 3) and lets you browse every thumbnail in a folder without using any of them: an image counts only when it opens in the viewer, a file that cannot be opened never counts, and an image you have already viewed reopens instantly.

SlideScope 1.8.58 includes fixes and improvements. Full release notes: https://slidescope.science/en/release-notes/

Zeiss slides scanned as several regions now open in full. Every scan region is reachable from the Scene selector, whatever size it is, and the XY Overview lays them all out at their real positions on the slide so you can go straight to any of them. Previously only the first region was shown, so the rest of the slide looked missing.

Slides open faster, and moving between them is quicker. SlideScope used to start a fresh image reader for every file, which cost the same whether the slide was two megabytes or two gigabytes; one is now ready and waiting before you choose a file. Nikon ND2 files also no longer read through the whole recording to show a single plane. Nothing about how images are read or displayed has changed.

Recent files, favourites, saved support contact details and the folders SlideScope reopens are now kept separately for each account, so a shared Mac no longer shows the previous person's slides after signing in. Signing in now explains your free image opens: what each one unlocks, and that nothing is charged and no trial begins until you choose to start it. Also included since the last App Store release: - Colour (RGB brightfield) CZI scans, such as H&E slides, now open. They previously failed with a scene/sample dimension error. - Multi-scene CZI files (well plates, tile regions, multi-position acquisitions) expose every scene as a stage position, with well names in the XY Overview. - Huge stitched ND2 frames from NIS-Elements Large Image acquisitions stream region by region instead of being refused for exceeding the memory budget. - Multiplex Vectra .qptiff scans open with every fluorescence channel available, instead of being flattened to a single colour image. - Whole-slide exports state the overview resolution they were saved at, instead of quietly saving a much smaller image than the scan. - Signed 8-bit and 16-bit images with a wide value range display with correct contrast instead of noise, and a plane containing invalid pixels no longer renders as a black frame. - The image information panel says when only part of a file is on screen. - ND2 acquisitions that stopped early show only the timepoints that were recorded, and say so.

When a supported file such as SVS, CZI, ND2, TIFF or DICOM cannot be opened, SlideScope now explains the problem and offers to send the technical details to support with one click. Support replies by email within 24 hours. The report carries only diagnostics: the file name, size and type, the loader and its version, where the open failed, and the error. The microscopy file itself is never uploaded. For files opened from a link, you choose whether to include the link in the support request; a link that carries an access token is shared without the token. Retrying the same file does not open another support request.

Individual subscriptions are now available directly in the app (monthly or annual, with a free trial), managed through your Apple ID. The account dialog gains Restore Purchases, Manage Subscription, Terms of Use and Privacy Policy links, and sign-in now uses the system authentication sheet. Also included: stability and reliability improvements. SlideScope now exits cleanly in every case, records diagnostics if a session ever ends unexpectedly, and automatically cleans up temporary folders left behind by interrupted sessions. Also fixes a scale-bar overlay background that did not render, improves combo-box popup rendering on macOS, and arranges the navigation bar into two rows for easier use on smaller displays.