COM – Oxygen consumption
Oxygraph simulator
Free · Designed for iPad. Not verified for macOS.
An oxygraph on screen: test substrates, inhibitors and uncouplers on isolated mitochondria and follow O₂ consumption and membrane potential.
COM simulates experiments with isolated mitochondria in an incubation chamber fitted with an oxygen electrode (oxygraph). Add mitochondria, substrates, ADP, inhibitors and uncouplers one after another and follow, in real time, O₂ consumption and the electrical potential of the inner membrane (Δψ).
The challenge is to find out what each compound does: which ones stimulate oxygen consumption, which ones inhibit it, where each electron transport chain inhibitor acts and how uncouplers separate respiration from ATP synthesis.
• 15 compounds: malate, pyruvate, α-ketoglutarate, succinate, TMPD + ascorbate, ADP + phosphate, rotenone, malonate, antimycin A, cyanide, carbon monoxide, oligomycin, 2,4-dinitrophenol and FCCP
• Recording of dissolved O₂ and Δψ, with a numbered history of every addition
• Several experiments side by side for comparison
• Question guide for undergraduate classes and an answer table for teachers
• Portuguese, English and Spanish
Current version of the COM simulator, created in 1997 at the Educational Technology Laboratory (LTE), Institute of Biology, University of Campinas (Unicamp), and used in biochemistry courses ever since. Part of BIOQUÍMICA +30.
Free, no ads, no sign-up and no data collection. Works offline.
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New version of COM, rebuilt from scratch: oxygraph simulator with 15 compounds, O₂ and Δψ recording, class guide, in Portuguese, English and Spanish. Works offline.
The developer, LTE-IB-UNICAMP, indicated that the app’s privacy practices may include handling of data as described below. For more information, see the developer’s privacy policy .
Data Not Collected
The developer does not collect any data from this app.
Accessibility
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Information
- Seller
- Eduardo Galembeck
- Size
- 2.3 MB
- Category
- Education
- Compatibility
Requires iOS 16.0 or later.
- iPhone
Requires iOS 16.0 or later. - iPad
Requires iPadOS 16.0 or later. - Mac
Requires macOS 13.0 or later and a Mac with Apple M1 chip or later.
- iPhone
- Languages
English and 2 more
- English, Portuguese, Spanish
- Age Rating
4+
- 4+
- Copyright
- © 1997–2026 LTE – IB Unicamp