Improvements to prevent the app from closing unexpectedly General stability and performance enhancements Updates to ensure compatibility with iOS 18

* Minor feature updates, including web-based user guide access to improve access to current resources  * Bug fixes, including appropriate indication when Bluetooth device used for pulse

Update for iOS 17.4 compatibility

Updated user interface and icons Updated for better iOS 16 compatibility Bug fixes, including use of keypad while using in-app phone call feature Added analytics to better understand how the app is used

Updated user interface and icons Updated for better iOS 15 compatibility Bug fixes, including use of keypad while using in-app phone call feature

• Supports phone calls to NxStage Support or Dialysis Center (requires WiFi connectivity) • Supports Virtual Sessions with video from the iPad camera for NxStage Technical Support or Dialysis Centers • Updated for better iOS 14 compatibility

• Supports Touch ID to allow logging in using a fingerprint • Supports Split View which allows Nx2me to be used at the same time as another app • Updated for better iOS 13 compatibility

• Supports Touch ID to allow logging in using a fingerprint • Supports Split View which allows Nx2me to be used at the same time as another app • Updated for better iOS 13 compatibility

• Flowsheets can include photos taken with the iPad camera as attachments • Dialysis centers and NxStage Technical Support can remotely view cycler data during therapy and NxStage Technical Support can request video from the iPad camera • Compatibility with iOS 12 • Screen auto-dimming and other enhancements

• The app now supports new VersiHD cycler • The app is now compatible with iOS 11 • Additional software enhancements

• New flowsheet calendar gives a five week view of treatments performed • The app now supports some Bluetooth thermometer models. These devices will allow you to automatically record temperature directly into the app • The app is now compatible with iOS 10 • Additional software enhancements

• Two-way messaging which allows patients and center staff to communicate with each other • Bluetooth blood pressure cuff and weight scale integration • New assessment questions have been added regarding Pre- and Post- Treatment labs. • Alarms received during treatment are recorded in the Confirm Screen. • Yellow cautions without a pop-up will no longer play a tone. • Additional software enhancements

·         New Synced column on the Home screen to indicate if a flowsheet was successfully synced. ·         A Streamlined Settings screen is available from all screens within the app.  This allows users to identify the network the iPad is connected.  ·         New connectivity messages are displayed to help troubleshoot directly within the app. ·         Additional software enhancements

• NxStage® System One™ S Cycler compatibility. • iOS8 compatibility • More detailed Pressure Graphs will display 2 minutes of pressure values at a given time as opposed to all treatment values for a given treatment. • The version of the NxStage System One User Guide within the app is NC4012 Rev B. The guide is also now formatted like an electronic book. • NxStage Wi-Fi Profile will install when creating a Nx2me account. • Additional software enhancements.

•More detailed Pressure Graphs will display 2 minutes of pressure values at a given time as opposed to all treatment values for a given treatment. •The version of the NxStage System One User Guide within the app is NC4012 Rev B. The guide is also now formatted like an electronic book. •NxStage Wi-Fi Profile will install when creating a Nx2me account. •Additional software enhancements.