This update from Apple will improve the functionality of this app. No new features are included. Fixed incompatibilities with iOS 8 which caused the app to freeze. Updated the user interface to iOS 7/8 look and feel.

User's can now enter custom PK/PD models for pediatric and veterinary use (in addition to adult specific models).

Maintenance release - bug fix.

- Users can now add additional drugs and custom PK/PD model parameters to the system - Added PK/PD models for Atracurium, Cisatracurium, Rocuronium, and Vecuronium

- User definable reference concentration lines - Case time base can be either "simulated" or "clock/real-time" - At startup the previous session's view is restored (i.e. you see what you were viewing when the app was last exited.

- iPad specific user interface o AnestAssist PK/PD 1.5 will run on both the iPod/iPhone and the new iPad (i.e. it is a "Universal App"). The iPad U/I is much more efficient (fewer screens), but functionality and features are the same for all devices. - Drug Given Graphs o Added "drug given" graphs showing timing and amounts of infusions and boluses. - Tap to display PK values o Tapping a point in the PK graph displays a cursor and numerical readout of the PK concentrations at that time. - PK Graph Display o Patient gender, weight, height, and age displayed. o Larger/bolder font used to increase readability. - Workflow and Configurability o After completing entry or edit of a drug given, the PK graph screen for the drug is immediately displayed. o Default bolus and infusion units for each drug can now be selected in Settings. o Units and graph limit/increment parameters for bolus given and infusion given graphs for each drug can be defined in Settings. o The "secondary" graph on the PK screen can be selected in Settings to default to either Interations/Effects or Drug Given.

New drugs: dexmedetomidine, ketamine, lidocaine, morphine, and midazolam. New models: additional/alternative models added for many supported drugs. Most (but not all) drugs now have at least one model using patient covariates. Isoflurane-opioid interaction effects model added. Many workflow/user interface improvements to speed drug entry and viewing. Additional units: mg/hr, mg/min, mcg/hr, mcg/min, mg/kg/hr Additional configuration options and model selections for all drugs. Model reference and patient covariate information for all drugs displayed. Graph time scale improvements. Bug fixes.

Inhaled modeling expanded and enhanced. - Agents supported: Sevoflurane, Isoflurane, Desflurane, Enflurane, Halothane, Nitrous Oxide - User control of vaporizer settings (%) and fresh gas flow (FGF) - Calculates and displays inspired (circuit) concentration, alveolar concentration, brain tissue concentration PK graphs can now be viewed in horizontal (landscape) orientation. Many user interface improvements. Bug fix for time round-off error in version 1.3

Inhaled modeling expanded and enhanced. - Agents supported: Sevoflurane, Isoflurane, Desflurane, Enflurane, Halothane, Nitrous Oxide - User control of vaporizer settings (%) and fresh gas flow (FGF) - Calculates and displays inspired (circuit) concentration, alveolar concentration, brain tissue concentration PK graphs can now be viewed in horizontal (landscape) orientation. Many user interface improvements.

- PK graph concentration axis fixed scale (upper limit and tic mark increment) for each drug can be set in Settings - Drug Given List entries can now be changed/edited by tapping them. - Default concentration for all drugs can be set in Settings

Correction to Sevoflurane PK model

Added inhaled agent modeling (Sevoflurane). Drug entry process improved, more unit types supported. Graphs show clock time, vertical axis auto-scales.