Plasmid editor
교육
￦7,700 · iPad용으로 디자인됨 · macOS용으로는 확인되지 않음
Import a SnapGene, GenBank or FASTA file. Every element is matched against the bases rather than trusted from the label, and each one is marked with how it was established: confirmed by exact sequence match, taken from the file's own annotation, or predicted from structure alone.
1. FOUR EDITS
Replace the promoter. Add a gene. Remove a gene. Swap a part.
Each one produces a finished construct, the Gibson assembly plan, and primers with melting temperatures. Homology arms extend until they are unique, so repeated sequence does not produce an ambiguous junction. Every design is re-assembled in silico before it is issued: if the product does not come back identical, you do not get the plan.
2. DESIGNS THAT WOULD HAVE FAILED QUIETLY
A cargo in a FLEX or DIO cassette is stored antisense. Paste a normally written coding sequence into those coordinates and it goes in backwards. The app works out the required orientation from the cassette architecture and places it correctly.
An annotated CDS is often only part of a longer reading frame. Replace just the annotated piece and your new gene inherits whatever sat in front of it — tags, targeting motifs, linkers - as an N-terminal fusion. The app reads upstream in frame, names what it finds, and offers to remove it.
3. PACKAGING SIZE, BEFORE YOU ORDER
The ITR-to-ITR genome is measured and compared against the real limit for AAV, self-complementary AAV, lentivirus or adenovirus. When a design is too large, you get specific reductions with the base pairs each one saves and what it costs you.
4. PROMOTERS AND CAPSIDS
Sixteen promoters covering neurons, astrocytes, hepatocytes, cardiomyocytes and ubiquitous expression. Each was read out of a publicly deposited plasmid map and carries the Addgene number and the exact coordinates it came from. They are exactly what that deposit contains - not sequence written from memory.
A capsid guide pairs cell types with AAV serotypes, each with the caveat that matters.
5. EXPORT
GenBank, SnapGene, or FASTA. Annotations, strands and topology survive the first two; FASTA is bases only, and the app says so before you pick it.
6. PRIVATE BY CONSTRUCTION
No account. No analytics. No advertising. Your vectors stay on your device. The app works offline; the one exception is an optional NCBI lookup when you type an accession, which sends nothing but that accession.
7. COMPANION APP
Gene Search, free, finds genes and accessions in NCBI and hands them straight to this app.
Gene Editing is a design aid. Every construct is a prediction from the sequence you supplied, and predictions can be wrong - most often because the file's own annotations were wrong. Verify every junction by sequencing before you rely on a construct.
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정보
- 제공자
- Reborn Pharmaceuticals, LLC
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- 31.4 MB
- 카테고리
- 교육
- 호환성
iOS 15.1 이상 필요
- iPhone
iOS 15.1 이상 필요 - iPad
iPadOS 15.1 이상 필요 - iPod touch
iOS 15.1 이상 필요 - Mac
macOS 12.0 이상 및 Apple M1 칩 이상이 탑재된 Mac이 필요 - Apple Vision
visionOS 1.0 이상 필요
- iPhone
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