This app has been updated by Apple to prepare for watchOS 27 compatibility. No new features are included. - Subscription bug fix.

- Minor bugs fixed

- Minor bugs - Corrected Ketamine kamp model name

-Added new Ketamine model: Domino-Navarrete - Fixed a bug that prevented to show estimated ACT

- Fixed a bug that prevented sharing cases through Airdrop / Whatsapp (Press More button, then Share)

- Fixed some bugs when adding manual boluses - Sufentanil Gets model is now divided in two models (Time to peak 5.8 min / T1/2 keo 6.2 min)

- Add decrement time curves / Mix up to 3 drug simulation in 1 graph- (Double tap the graph, the press button (+) - Added a info box to display graph concentration and more info

- Added Lidocaine pK model for children (Finholt, 1986): 6 months to 13 years - Added Dexmedetomidine pharmacodynamic interactions with remifentanil, propofol and inhaled anesthetics (This interaction is additive over hypnotics) - Now Dexmedetomidine Hannivoort pk model is separated in MOAA/S for clinical sedation and BIS for BIS value prediction - Resolved a bug in the Fentanyl / Shafer (adjusted weight) model - Addressed an issue related to file loading - Enhanced file-saving functionality, making it more intuitive and efficient

- Added Dexmedetomidine pharmacodynamic interactions with remifentanil, propofol and inhaled anesthetics (This interaction is additive over hypnotics) - Now Dexmedetomidine Hannivoort pk model is separated in MOAA/S for clinical sedation and BIS for BIS value prediction

- Sugammadex PK Model: Optimize dose calculation for TOF-r of 100% with rocuronium interaction. - Effortless Induction: Try the new "Bolus/Non-Stop" mode for smoother setup via simultaneous bolus and infusion. - Enhanced TCI Algorithm: Ensure precise drug delivery with advanced Target-Controlled Infusion. - iPhone 14 Ready: Enjoy full compatibility and a seamless experience.

- Minor bugs fixed - New PK model for Remimazolam (Masui, 2022) - Improved iOS 16 compatibly

- Now initial target (Start and maintenance) can be set after real-time is on - Minor bugs fixed

- Fixed a bug when opening files - New PK model for Dexmedetomidine in neonates: Zuppa BJA model 2019:123(6):839 - Improved TCI algorithm

- New PK model for Dexmedetomidine in neonates: Zappa model BJA 2019: 123(6):839 - TCI algorithm improved

- Improved TCI algorithm for better accuracy with fewer infusion changes. -Now you can modify the accuracy of the algorithm between 99% or 95%, to calculate a simpler scheme but with lower accuracy. Tap the "More" button to modify the accuracy - New option for induction calculation, go to settings and enable "Bolus/Infusion without delay" to calculate an initial scheme with a bolus and an infusion starting at the same time

- Create templates to build generic schemes, to more quickly set up your induction scheme, to then perform a fine titration using iTIVA - Morse general model for Dexmedetomidine added (for kids and Adults) - Do a long tap in the scheme list to COPY/PASTE any infusion scheme, you can choose to copy in ML/hr or according the patient weight - Share your case through Whatsapp or Airdrop in 2 taps, Tap "MORE" button and then "SHARE"

- PK/PD graph now can be set in full screen double tapping - Added 6 pharmacodynamics models to explore interaction between opioids and propofol / Sevoflurane - Added PD BIS prediction for propofol Eleveld's model - Increase simulation speed up to 30 times, ideal for teaching and workshops - Added real-time decrement time calculation: Swipe to the right in the horizontal bars - Added Scott PK model for Alfentanil

- Remimazolam added - Etomidate added - ICU PK models for Midazolam added - Minor issues fixed

- New feature: set a custom Ke0, using the "TIME TO PEAK" method, so now you can modify the pharmacodynamics of any model. The "time to peak" is the time from the first bolus to the maximum effect measured (using any method, clinical, EEG, BIS, entropy, etc.). To SET a new "TIME TO PEAK", add a new anesthetic drug, tap the "More" button (in the lower right corner) and then "TIME TO PEAK". - New feature: Pre-alerts, iTIVA will generate a warning sound before any infusion change, to modify this option open the menu -> Configuration

- Fixed some text size issues in the lateral menu after last update - Added a FILE MANAGER: NOW you can save your simulation cases to review them later, share with colleagues (e-mail, WhatsApp or AirDrop) or run multiple simulations at time. - Set the end time of your simulation cases and save them for later analysis. (Press the MORE button -> END CASE) - Select custom alert tones for iTIVA notifications: You can pick over 40 different tones. (Go to Setting-> Tones) - Added a new ketamine model: Klamp - Eleveld-h model renamed to Eleveld 1.0 - Obese adjustments mode deleted, now models are filter according the best evidence - Minto model for remifentanil now can be selected using James equation (original) or Janmahastian (For obese pts) to calculated the lean body mass - Shafer model for fentanyl now have 3 options, without covariables, real weight and adjusted weight for obeses patients over 80 kg - Minor bugs fixed

- Added a file manager: Now you can save your simulation cases to review them later, share with colleagues (e-mail, WhatsApp or AirDrop) or run multiple simulations at time. - Set the end time of your simulation cases and save them for later analysis. (Press the MORE button -> END CASE) - Select custom alert tones for iTIVA notifications: You can pick over 40 different tones. (Go to Setting-> Tones) - Added a new ketamine model: Klamp - Eleveld-h model renamed to Eleveld 1.0 - Obese adjustments mode deleted, now models are filter according the best evidence - Minto model for remifentanil now can be selected using James equation (original) or Janmahastian (For obese pts) to calculated the lean body mass - Shafer model for fentanyl now have 3 options, without covariables, real weight and adjusted weight for obeses patients over 80 kg - Minor bugs fixed

- Fixed a bug added in the last update that impeded the correct data transfer using QR codes - Fixed some errors in the rocuronium PK models - Thanks to Dr. Eleveld - Enter individual Cr clearances or serum Cr when using Kleijn's model for rocuronium - Now you can switch between bolus or infusion mode, just double-tap over the horizontals bars - Fixed some screen size mismatch issues with some iPhone models

- Fixed some errors in the rocuronium PK models - Thanks to Dr. Eleveld - Enter individual Cr clearances or serum Cr when using Kleijn's model for rocuronium - Now you can switch between bolus or infusion mode, just double-tap over the horizontals bars - Fixed some screen size mismatch issues with some iPhone models - Minor bugs fixed

- Minor bugs fixed that should decrease random crashes. - Fixed some bugs that crashed the App when using mixed drugs - Now drugs can be synchronized while in real-time mode. - New option for synchronizing drugs: now you can choose if want to include the boluses while synchronizing, so boluses doses can keep independent while infusion keeps sync. - Cr clearance calculation added to the first aid library - Minor improvements in the PK/PD graph

- Improved TCI algorithm:  - Fewer modifications to achieve a new target with a 98% precision - Low target precision improved - Minor bug fixes