Set minimum iOS version to 15.0

Requires iOS 13 Supports Dark Mode

Updated to support iOS 11

Compatible with iOS 9 Uses numeric keypad for data entry If you like RxCalc, please take a moment to leave a review, it really helps! If not, please send your feedback to support@applecorelabs.com or visit http://applecorelabs.com/contact/ for help.

1. iPhone 5 bug fixes 2. Requires iOS 5 or newer Plus all this... 1. Support for dosing adjustment using single level vancomycin kinetics a. The calculations are performed using both patient specific information supplied by the user as well as patient population parameters. 2. Literature supported High Dose Extended Interval (HDEI) (aka "once daily" or "pulse") aminoglycoside dosing b. Calculations for gentamicin and tobramycin are based on 7mg/kg adjusted body weight c. Calculations for amikacin are based on 15mg/kg adjusted body weight RxCalc formula/models: 1. Industry standards for ideal body weight (IBW) calculations 2. Cockcroft-Gault equation for creatinine clearance calculations 3. Vancomycin utilizes the Creighton model for calculations: a. Kel = 0.0044 + (CrCl x 0.00083) b. Vd = 0.7 L/kg (using actual patient body weight) c. Vancomycin Vd is adjustable based on user need between 0.5 L/kg and 1 L/kg (default 0.7 L/kg) 4. Aminoglycoside model utilizes the following: a. Kel = (0.14 + (0.00293 * CrCl) b. Vd 0.26 L/kg (using adjusted patient body weight) a. Aminoglycoside Vd is adjustable based on user need between 0.2 L/kg and 0.5 L/kg (default 0.26 L/kg) b. Adjusted body weight for aminoglycoside calculations is calculated as follows: IBW + ((ActBW - IBW) x 0.4)

Release 1.2 of RxCalc adds improved functionality including: 1. Support for dosing adjustment using single level vancomycin kinetics a. The calculations are performed using both patient specific information supplied by the user as well as patient population parameters. 2. Literature supported High Dose Extended Interval (HDEI) (aka "once daily" or "pulse") aminoglycoside dosing b. Calculations for gentamicin and tobramycin are based on 7mg/kg adjusted body weight c. Calculations for amikacin are based on 15mg/kg adjusted body weight RxCalc formula/models: 1. Industry standards for ideal body weight (IBW) calculations 2. Cockcroft-Gault equation for creatinine clearance calculations 3. Vancomycin utilizes the Creighton model for calculations: a. Kel = 0.0044 + (CrCl x 0.00083) b. Vd = 0.7 L/kg (using actual patient body weight) c. Vancomycin Vd is adjustable based on user need between 0.5 L/kg and 1 L/kg (default 0.7 L/kg) 4. Aminoglycoside model utilizes the following: a. Kel = (0.14 + (0.00293 * CrCl) b. Vd 0.26 L/kg (using adjusted patient body weight) a. Aminoglycoside Vd is adjustable based on user need between 0.2 L/kg and 0.5 L/kg (default 0.26 L/kg) b. Adjusted body weight for aminoglycoside calculations is calculated as follows: IBW + ((ActBW - IBW) x 0.4)

Customize Units of Measure 1) Height - Inches or Centimeters 2) Weight - Pounds or Kilograms 3) SCr - mg/dL or micromol/L Customize Volume of Distribution 1) Aminoglycoside - Between .20 and .50 2) Vancomycin - Between .50 and 1.0 Usability Enhancements The User Interface is now less rigid. Now allows scrolling while the keyboard is showing. You can freely move between cells without seeing the "Zero value" error.

Fixed a usability problem that hid the final adjustment table section. Now auto scrolls to the section.